Assessment of allergen tolerance breakdown levels in local and classical allergic rhinitis

Local allergic rhinitis, a new endotype of rhinitis discerned by researchers the Spanish Allergy School, is now in focus interest international allergological community. A special feature local which, being similar to conventional signs is, however, characterized absence systemic atopy manifestations, e.g., an increased total serum IgE content and positive skin tests. In order assess level tolerance breakdown allergens classical we have studyed concentrations IL-4, IL-22, IFNγ three biological fluids, blood, nasal secretions, exudate. The whole study cohort consisted 82 patients aged 18 60 years with established rhinitis. diagnosis was based on counseling allergologist/immunologist, including clinical case history possible inheritance as well videorhinoscopy performed ENT specialist. procedure allowed specify origin exclude non-allergic forms disease, but it did not enable us differentiate between endotypes classic Subsequently, all been divided into two subgroups criteria atopy: (1) high allergy tests (n = 41) (2) significantly lower concentration negative 41). It concluded that prevailed 1 st subgroup, whereas predominated 2 nd group. IL-22 fluids presume subgroup IL-4 blood exudate comparison controls, showed decrease control values. cytokine secretions were representative for studied. result has interpreted causal at level. obtained data could be used development diagnostic biomarker system this specific thus avoiding potential errors which occurred past, when classified form administering non-adequate treatment, allergen-specific immunotherapy, prescribed these cases.